Cerenia for Nausea in Cats

Hickman, M. A., S. R. Cox, et al. (2008). "Safety, pharmacokinetics and use of the novel NK-1 receptor antagonist maropitant (Cerenia) for the prevention of emesis and motion sickness in cats." Journal of Veterinary Pharmacology and Therapeutics 31(3): 220-229.

Maropitant (Cerenia, Pfizer Animal Health) is a selective NK-1 receptor antagonist that has anti-emetic effects. It is licensed for oral use in dogs in the United States. In this study, maropitant was administered to cats at doses ranging from 0.5 to 5.0 mg/kg subcutaneously (SC) for 15 days. No adverse effects were found at any dose, including doses that exceed the anti-emetic dose by a factor of 10. The pharmacokinetics of maropitant were determined following single dose oral, intravenous, and SC administration. Anti-emesis efficacy was determined against xylazine or motion. A dosage of 1 mg/kg maropitant administered IV, SC or PO prevented emesis elicited by xylazine. The results indicate that maropitant is an effective, well tolerated and safe anti-emetic in cats at a dose of 1.0 mg/kg with a 24-hour duration of action.
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Related articles:
de la Puente-Redondo, V. A., E. M. Siedek, et al. (2007). "The anti-emetic efficacy of maropitant (Cerenia) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe." J Small Anim Pract 48(2): 93-8.
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Terbinafine for Feline Ringworm

Foust, A. L., R. Marsella, et al. (2007). "Evaluation of persistence of terbinafine in the hair of normal cats after 14 days of daily therapy." Vet Dermatol 18(4): 246-51.

Microsoporum canis is the dermatophyte most commonly associated with ringworm in cats. Several drugs have been used for treatment of M. canis in cats, including itraconazole, griseofulvin, and terbinafine. Terbinafine (Lamisil, Novartis) is of interest because in other species, it shows good penetration into affected tissues, efficacy with short durations of treatment, and is well tolerated. Few studies have been conducted on the use of terbinafine in cats. In this study, the residual concentration of terbinafine in cat hair was determined after 14 days of oral treatment. Ten normal cats were administered terbinafine at a daily dose of 34-45 mg/kg for 14 days. Hair samples were analyzed at day 0, and weekly for 8 weeks after the last dose of terbinafine. With a 99% confidence interval, the concentration of terbinafine remained above the minimal inhibitory concentration (MIC) for 5 weeks. Four cats experienced vomiting during treatment, and two of these cats experienced intense facial pruritus 7 to 14 days after the end of treatment. The researchers concluded that terbinafine persists in cat hair at concentrations above the MIC for several weeks after the end of therapy, even when treated for only 14 days. Pulse therapy using terbinafine is worth further investigation for the treatment of feline ringworm.
>> PubMed abstract

Related articles:
Mancianti, F., F. Pedonese, et al. (1999). "Efficacy of oral terbinafine in feline dermatophytosis due to Microsporum canis." J Fel Med Surg 1(1): 37.
>> PubMed abstract

Kotnik, T. (2002). "Drug efficacy of terbinafine hydrochloride (Lamisil) during oral treatment of cats, experimentally infected with Microsporum canis." J Vet Med B Infect Dis Vet Public Health 49(3): 120-122.
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Clostridium difficile in Hospitalized Cats

Clooten, J., S. Kruth, et al. (2008). "Prevalence and risk factors for Clostridium difficile colonization in dogs and cats hospitalized in an intensive care unit." Vet Microbiol 129(1-2): 209-14.

Clostridium difficile is the most common cause of hospital- and antimicrobial-associated diarrhea in hospitalized humans. A prospective study of C. difficile colonization in dogs and cats was conducted in a veterinary teaching hospital intensive care unit (ICU). Rectal swabs were taken from patients upon admission to the ICU and every third day of hospitalization until discharge or death. C. difficile was isolated from 73/402 (18%) animals; 69% of isolates were toxigenic. Community-associated colonization was identified in 39/366 (11%) of animals that were sampled at the time of admission, while C. difficile was subsequently isolated from 27 of the remaining 327 (8.3%) animals that had a negative admission swab. Administration of antimicrobials prior to admission and administration of immunosuppressive drugs during hospitalization were risk factors for hospital-associated colonization. Acquisition of C. difficile during hospitalization in the ICU was associated with the development of diarrhea.
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Related articles:
Weese, J. and J. Armstrong (2003). "Outbreak of Clostridium difficile-associated disease in a small animal veterinary teaching hospital." J Vet Intern Med 17(6): 813-816.
>> PubMed abstract

Madewell, B. R., J. K. Bea, et al. (1999). "Clostridium difficile: a survey of fecal carriage in cats in a veterinary medical teaching hospital." J Vet Diagn Invest 11(1): 50-4.
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Sources of Pet Health Information Used by Owners

Kogan, L. R., G. Goldwaser, et al. (2008). "Sources and frequency of use of pet health information and level of confidence in information accuracy, as reported by owners visiting small animal veterinary practices." J Am Vet Med Assoc 232(10): 1536-42.

Although most people look to their physicians for health care information, they also utilize other sources, such as mass media. A survey conducted in 2005 determined that 74% of American adults are using the internet as a health information resource. Despite this statistic, many physicians appear unaware of the frequency with which their patients are accessing internet sites for health information. The purpose of the study reported here was to gain a better understanding of the various sources of pet health information and the frequency of their use and to assess the level of confidence in information accuracy, as reported by pet owners who visit their veterinarians. Seventeen small animal clinics in Fort Collins, Colorado were recruited to participate in the study. Study questionnaires were distributed to each clinic; staff recruited participants by asking all individuals who entered their clinic to anonymously complete a survey. The survey contained questions on owner demograhics. Other questions included species of pet that was brought to the clinic at that visit, the number of times the participant had visited the veterinary clinic in the past 12 months, and frequency of use and confidence in various sources of pet health information. Results indicated that pet owners who visited their veterinarians acquired pet information from veterinarians via the telephone or in person and from family or friends more frequently than they acquired such information from the internet. Pet owners also reported more confidence in information received from veterinarians compared with information from any other accessible source.
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Bacterial Urinary Tract Infections in Cats

Eggertsdottir, A. V., H. S. Lund, et al. (2007). "Bacteriuria in cats with feline lower urinary tract disease: a clinical study of 134 cases in Norway." J Feline Med Surg 9(6): 458-65.

Feline lower urinary tract disease (FLUTD) is a common diagnosis. Idiopathic cystitis is considered the most common cause, with bacterial cystitis traditionally accounting for less than 2% of cases in cats under the age of 10 years. In this retrospective study, 134 cats that presented with signs of lower urinary tract disorders were included in a project at the Norwegian School of Veterinary Science. All the cats had a physical examination, blood samples were collected for haematology and clinical chemistry, and a full urinalysis with culture was performed. The urine samples were collected as voided mid-stream urine samples, by catheter or by cystocentesis. Of the 134 cats included in the study, 37% were diagnosed as having obstructive and 63% as having non-obstructive FLUTD. In total, 44 cats (33%) were diagnosed with bacteriuria. No significant difference was found between the sampling methods performed with regard to bacteriuria. This study indicates that bacteriuria may have been underdiagnosed in Norwegian cats with clinical signs of FLUTD. Further research is needed to establish the prevalence of the causes of FLUTD in Europe and the USA.
>> PubMed abstract

Related articles:
Dru Forrester, S. and P. Roudebush (2007). "Evidence-based management of feline lower urinary tract disease." Vet Clin North Am Small Anim Pract 37(3): 533-58.
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Protozoal Parasites in Cats with Diarrhea

Tzannes, S., D. J. Batchelor, et al. (2008). "Prevalence of Cryptosporidium, Giardia and Isospora species infections in pet cats with clinical signs of gastrointestinal disease." J Feline Med Surg 10(1): 1-8.

The protozoal parasites Cryptosporidium, Giardia, and Isospora cause signs of gastrointestinal disease in many mammal species. Cryptosporidium and Giardia are important infections of immunocompromised people. The prevalence of Giardia and Cryptosporidium in cats varies worldwide, with rates up to 80%. In kittens, Isospora species infection may result in diarrhea that may be mucoid or bloody. The infection is common around the world, with a reported prevalence as high as 44%. This study aimed to evaluate prevalence of Cryptosporidium species, Giardia duodenalis and Isospora species infection in a cohort of cats displaying signs of gastrointestinal disease and to identify if demographic factors, such as signalment, region or season, were correlated with prevalence. Records from a United Kingdom commercial diagnostic laboratory between December 2003 and December 2005 were reviewed. Of 1355 cats, Cryptosporidium species oocysts were found in 13 cats (1%), Giardia species trophozoites in 74 (6%), and Isospora felis oocysts in 46 (3%). Prevalence of Giardia (9%) and Isospora (9%) species was higher in cats less than 6 months old. Gender and breed did not affect prevalence. This study demonstrates that enteric protozoal infection is common in domestic cats showing signs of gastrointestinal disease.
>> PubMed abstract

Related articles:
Mekaru, S. R., S. L. Marks, et al. (2007). "Comparison of direct immunofluorescence, immunoassays, and fecal flotation for detection of Cryptosporidium spp. and Giardia spp. in naturally exposed cats in 4 Northern California animal shelters." J Vet Intern Med 21(5): 959-65.
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Causes of Gingivitis in Cats

Quimby, J. M., T. Elston, et al. (2008). "Evaluation of the association of Bartonella species, feline herpesvirus 1, feline calicivirus, feline leukemia virus and feline immunodeficiency virus with chronic feline gingivostomatitis." J Feline Med Surg 10(1): 66-72.

Gingivostomatitis is a common medical condition in cats. Clinical signs include red and swollen gums that may bleed easily, halitosis, and oral pain. The discomfort can lead to dysphagia, decreased appetite, and weight loss. The syndrome is likely to be multifactorial and it is suspected to involve an exaggerated immune response to either infectious or non-infectious antigens. Other factors that may be involved include genetic predispostion, diet, stressors, and the effects of domestication. Several infectious agents have been found in cats with gingivostomatitis such as feline leukemia virus (FeLV), feline immunodeficiency virus (FIV), calicivirus (FCV), herpesvirus (FHV-1), and Bartonella. However, all these agents can also be found in healthy cats so proving cause and effect has been difficult. The 45 cats in this study were housed together, had a history of flea exposure, and were vaccinated with a modified live FVRCP vaccine. At the time of sample collection, 36 of the cats had active gingivostomatitis. Samples were collected and analyzed for infectious agents. All of the agents were found in the population with the exception of FeLV. However, evidence of infection with Bartonella species, FHV-1, FCV, FeLV or FIV was not overrepresented in the cats with gingivostomatitis and so the data fail to support the hypotheses that these organisms were a cause of gingivostomatitis in this population of cats. The researchers conclude that diagnostic test results for these infectious agents should be interpreted carefully as none appear to correlate to the presence or absence of disease.
>> PubMed abstract

Related articles:
Southerden, P. and C. Gorrel (2007). "Treatment of a case of refractory feline chronic gingivostomatitis with feline recombinant interferon omega." J Small Anim Pract 48(2): 104-6.
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Feline Cardiomyopathy and Thromboembolism

Winn funded research

Stokol, T., M. Brooks, et al. (2008). "Hypercoagulability in cats with cardiomyopathy." J Vet Intern Med 22(3): 546-552.

Arterial thromboembolism (ATE) is a serious and often fatal complication of cardiomyopathy in cats. Thromboemboli are believed to originate from clots in the left atrium or left atrial appendage. The factors causing clot formation are not fully understood. In this study, the researchers hypothesized that cats with cardiomyopathy develop ATE because they are in a systemic hypercoagulable state or have underlying endothelial (arterial or endocardial) injury. Healthy cats (n=30) and 3 groups of cats with cardiomyopathy were studied. Group 1 cats had left atrial enlargement (LAE) only. Group 2 cats had LAE with spontaneous echocardiographic contrast, atrial thrombi or both. Group 3 cats had acute ATE with LAE. Coagulation status was assessed in all three groups, including fibroginogen, Factor VIII, antithrombin, thrombin-antithrombin complex (TAT) and D-dimer concentrations. The 3 groups of cats with cardiac disease had higher median fibrinogen concentrations than did the healthy cats. Criteria of hypercoagulability were found exclusively in group 2 and group 3 cats. Hypercoagulability was not associated with left atrial size or congestive heart failure. Systemic hypercoagulability is evident in many cats with cardiomyopathy, often without concurrent congestive heart failure or overt ATE, and may represent a risk factor for ATE. The researchers concluded that the pathogenesis of ATE is multifactorial and therefore treatment and prevention of this syndrome might involve drug combinations modulating hemostasis and inflammatory pathways.

>> PubMed abstract

Related articles:

Bedard, C., A. Lanevschi-Pietersma, et al. (2007). "Evaluation of coagulation markers in the plasma of healthy cats and cats with asymptomatic hypertrophic cardiomyopathy." Vet Clin Pathol 36(2): 167-72.

>> PubMed abstract

Brazzell, J. L. and D. L. Borjesson (2007). "Evaluation of plasma antithrombin activity and D-dimer concentration in populations of healthy cats, clinically ill cats, and cats with cardiomyopathy." Vet Clin Pathol 36(1): 79-84.

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Insulinoma in a Cat

Greene, S. N. and R. M. Bright (2008). "Insulinoma in a cat." J Small Anim Pract 49(1): 38-40.

Insulinomas are functional pancreatic tumors producing insulin. The abnormal release of insulin drives blood glucose concentrations below normal and produces the typical clinical signs associated with insulinoma (e.g., seizures, weakness, collapse, muscle twitching, etc.). They are uncommon tumours in dogs and cats and are often malignant. Insulinomas are suspected when an adult cat is presented with suggestive clinical signs and persistent hypoglycemia. In this case report, a 14-year-old domestic shorthair cat was presented with seizures and hypoglycemia. Investigation revealed low blood glucose concurrent with normal insulin levels. Medical and dietary management were attempted without success. At exploratory laparotomy, a well-defined mass was found in the pancreas. The mass was resected and identified on histopathology as an islet cell carcinoma - consistent with an insulinoma. The patient has had no recurrence of clinical signs in over 32 months post-surgery. This case is unique because of the apparent lack of local recurrence and development of metastatic disease, leading to the prolonged survival.
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Related articles:
Kraje, A. (2003). "Hypoglycemia and irreversible neurologic complications in a cat with insulinoma." J Amer Vet Med Assoc 223(6): 812-814.
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Kidney Insufficiency After Treatment for Feline Hyperthyroidism

Riensche, M. R., T. K. Graves, et al. (2008). "An investigation of predictors of renal insufficiency following treatment of hyperthyroidism in cats." J Feline Med Surg 10(2): 160-6.

Renal insufficiency is a common finding in older cats, affecting about 30% of cats over age 15. Hyperthyroidism is the most common endocrine disorder in cats, and it appears to be increasing in incidence over time. Hyperthyroidism can mask underlying renal disease by causing an increase in the glomerular filtration rate (GFR). Treatment of hyperthyroidism leads to a decrease in GFR and an increase in blood urea nitrogen (BUN). Different treatments exist for hyperthyroidism in cats, including reversible (methimazole) and irreversible (thyroidectomy, radioiodine) options. The ability to predict which cats will develop renal insufficiency after treatment for hyperthyroidism would help guide treatment decisions. The purpose of this retrospective study was to determine if routine pre-treatment clinical data can be used to predict the development of overt renal insufficiency following treatment of feline hyperthyroidism. Medical records were reviewed for 39 nonazotemic cats undergoing treatment for hyperthyroidism at the College of Veterinary Medicine, University of Illinois. The records were reviewed for for signalment, clinical signs, and serum biochemical, hematologic and urinalysis findings before and after treatment for hyperthyroidism. Cats that developed renal insufficiency within 6 months after treatment (n=20) were compared to cats that did not (n=19). No significant differences could be detected between the groups with respect to the parameters measured. The study suggests that the results of routine pre-treatment clinical data cannot be used to predict renal function after treatment for hyperthyroidism, and that a trial of methimazole therapy is indicated before choosing irreversible treatment such as radioiodine.
>> PubMed abstract

Related articles:
Boag, A. K., R. Neiger, et al. (2007). "Changes in the glomerular filtration rate of 27 cats with hyperthyroidism after treatment with radioactive iodine." Vet Rec 161(21): 711-5.
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Helicobacter and Lymphoma in Cats

Bridgeford, E. C., R. P. Marini, et al. (2008). "Gastric Helicobacter species as a cause of feline gastric lymphoma: A viable hypothesis." Vet Immunol Immunopathol 123(1-2): 106-13.

In humans and other animals, gastric Helicobacter spp. bacteria are associated with chronic inflammation. In this study, the relationship between Helicobacter heilmannii and gastric lymphoma in cats was examined. Gastric specimens were collected via biopsy or at necropsy from 47 pet cats with clinical signs of gastrointestinal disease, such as vomiting and anorexia. The specimens were characterized as gastritis (14/47), lymphoma (31/47), or normal (2/47). Staining for Helicobacter organisms was positive in 29 of the specimens. These tissues were then further examined to determine the Helicobacter species involved. Of the cats characterized as having lymphoblastic lymphoma, 13/17 were positive for H. heilmannii. The association between gastric lymphoma in cats and H. heilmannii infection requires further investigation, especially to evaluate the frequency and strain distribution of H. heilmanni in both well cats and those with gastric lymphoma using prospective studies.
>> PubMed abstract

Related articles:
Priestnall, S. L., B. Wiinberg, et al. (2004). "Evaluation of "Helicobacter heilmannii" subtypes in the gastric mucosas of cats and dogs." J Clin Microbiol 42(5): 2144-51.
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Congenital Abnormalities of the Feline Spine

Newitt, A., A. J. German, et al. (2008). "Congenital abnormalities of the feline vertebral column." Vet Radiol Ultrasound 49(1): 35-41.

In this retrospective study, radiographs from 200 cats were assessed to determine the incidence of congenital abnormalities of the spinal column. Congenital abnormalities were found in 46 cats (23%). No cats were identified with hemivertebrae or spina bifida, although block vertebrae were found in three cats. Transitional abnormalities were the most common, such as thoracicization of L1 (18 cats; 9%) and extra ribs on L1. Extra ribs were often smaller and fragmented and could be confused with rib fractures.
>> PubMed abstract

Related articles:
Bailey, C. S. and J. P. Morgan (1992). "Congenital spinal malformations." Vet Clin North Am Small Anim Pract 22(4): 985-1015.
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Heart Failure in Diabetic Cats

Little, C. J. and G. Gettinby (2008). "Heart failure is common in diabetic cats: findings from a retrospective case-controlled study in first-opinion practice." J Small Anim Pract 49(1): 17-25.

Diabetes mellitus is a common disease in cats and the prevalence may be increasing. In people, death associated with diabetes is commonly due to cardiovascular disease. The purpose of this retrospective study was to examine the prognosis and cause of death in cats with diabetes mellitus diagnosed between 1999 and 2005 at a veterinary hospital in Kent, England. Nineteen cats with diabetes were each matched with three age-, breed-, and gender-matched control cats without diabetes. The incidence of heart disease in the diabetic cats was 26% versus 3.5% in the control cats. Cats with diabetes were 10.4 times more likely to have heart disease than non-diabetic cats. Survival time was significantly worse for cats with diabetes (median 385 days) versus control cats (median 718 days). All cats with heart failure died or were euthanized soon after the diagnosis. This study concluded that heart disease and failure is common in this population of cats with diabetes.
>> PubMed abstract

Related articles:
Ployngam, T., A. H. Tobias, et al. (2006). "Hemodynamic effects of methylprednisolone acetate administration in cats." Am J Vet Res 67(4): 583-7.
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Streptococcus canis Infections in Cats

Sura, R., L. S. Hinckley, et al. (2008). "Fatal necrotising fasciitis and myositis in a cat associated with Streptococcus canis." Vet Rec 162(14): 450-3.


Streptococcus canis (Lancefield group G) is present in about 10% of cultures of the nasal cavity from cats with upper respiratory tract disease. In cats, S. canis has been associated with arthritis, urogenital infections, upper respiratory tract infections, and neonatal septicemia. Necrotizing fasciitis and necrotizing myositis are rare manifestations of streptococcal infections known to occur in humans and dogs. Most of these cases are caused by streptococci of Lancefield groups A, B, or G. Necrotizing fasciitis has only been reported twice in cats to date. This paper describes a fatal case of necrotizing fasciitis and myositis with pneumonia and septicemia in a 9-year old cat associated with S. canis infection.
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Related articles:
Pesavento, P. A., M. J. Bannasch, et al. (2007). "Fatal Streptococcus canis infections in intensively housed shelter cats." Vet Pathol 44(2): 218-21.
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Intervertebral Disk Disease in Cats

Harris, J. E. and S. Dhupa (2008). "Lumbosacral intervertebral disk disease in six cats." J Am Anim Hosp Assoc 44(3): 109-15.

Intervertebral disk disease (IVDD) in the lumbosacral spine is a common problem in dogs, but little is known about IVDD in cats. Although disk degeneration and protrusion may be found at necropsy in cats, IVDD is not usually accompanied by recognizable clinical signs. This retrospective study was performed to evaluate clinical signs and surgical outcomes in six cats diagnosed with lumbosacral IVDD. Clinical signs included reluctance to jump, carrying the tail low, inappropriate elimination, reluctance to walk, pelvic-limb paresis, urinary incontinence, and constipation. With one exception, all cats had long-standing clinical histories and clinical signs attributable to lumbosacral disease. Each of the six cats underwent dorsal decompressive laminectomy at the L7 to S1 interspace. Postoperative clinical follow-up lasted 3 to 35 months, with most cats having excellent outcomes. The authors conclude that the incidence of lumbosacral IVDD in cats may be higher than previously recognized. Lumbosacral IVDD should be considered as a differential diagnosis in all cats having caudal lumbar pain or pain on tail hyperextension.
>> PubMed abstract

Related articles:
Kathmann, I., S. Cizinauskas, et al. (2000). "Spontaneous lumbar intervertebral disc protrusion in cats: literature review and case presentations." J Feline Med Surg 2(4): 207-12.
>> PubMed abstract

Knipe, M., K. Vernau, et al. (2001). "Intervertebral disc extrusion in six cats." J Fel Med Surg 3(3): 161-168.
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Cetirizine For Allergies in Cats

Papich, M. G., E. K. Schooley, et al. (2008). "Pharmacokinetics of cetirizine in healthy cats." Am J Vet Res 69(5): 670-4.

Cats may suffer from various manifestations of allergic disease affecting body systems such as the skin, respiratory tract, and gastrointestinal tract. Glucocorticoids such as prednisone are effective for treating allergic disease in cats, but may be associated with undesirable adverse effects. Cetirizine (Zyrtec, Pfizer), a second-generation antihistamine, is effective in humans for treatment of allergic symptoms and appears to have less adverse effects than first-generation antihistamines. Although there is anecdotal information about the use of cetirizine in cats, no published pharmacokinetic studies exist and an appropriate oral dose has not been established. In this study, the pharmacokinetic characteristics of cetirizine after oral administration of a single dose was characterized in cats. Each of nine healthy cats was given a single oral dose of 5 mg cetirizine. Blood samples were collected at various time points up to 24 hours after administration and plasma concentrations of cetirizine were analyzed. Cats given this single oral dose of cetirizine had high plasma concentrations compared with those reported in humans, a long halflife, and lack of detectable adverse effects. The results support once daily dosing of cetirizine in cats. Further studies evaluating the therapeutic efficacy of this drug in cats with allergic disease need to be performed, as well as multipledose pharmacokinetic and safety studies. It appears that cetirizine may be a useful alternative to glucocorticoids in cats with allergic disease.
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Feline Permethrin Spot-On Toxicity

Sutton, N. M., N. Bates, et al. (2007). "Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons Information Service (VPIS), London." J Feline Med Surg 9(4): 335-9.

Permethrin is a pyrethroid insecticide used in topically applied spot-on flea treatments for dogs. Cats are very sensitive to the toxic effects of permethrin. These products are readily available and are often less expensive than other flea control products. Cats may be affected when the product is applied directly to them, or through contact with a treated animal. Data from 286 cases of permethrin toxicity in cats from the Veterinary Poisons Information Service in the United Kingdom is reviewed. The majority of the cats (96.9%) experienced clinical signs of toxicosis. The most common clinical signs were twitching, tremors, muscle fasciculations, and seizures. The duration of clinical signs was long, with seizures lasting an average of 38 hours and tremors lasting an average of 32 hours. Some cats took up to 1 week to recover. Death occurred in 10.5% of cases, some of which were euthanized due to reasons such as respiratory failure, or uncontrollable seizures. It is very important for cat owners to avoid using spot-on flea products containing permethrin on cats, and cats should not have contact with other animals treated with these products.
>> PubMed abstract

Related articles:
Linnett, P. J. (2008). "Permethrin toxicosis in cats." Aust Vet J 86(1-2): 32-5.
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Cognitive Dysfunction in Senior Cats

Crowell-Davis, S. L. (2008). "Cognitive dysfunction in senior pets." Comp Contin Edu Pract Vet 30(2): 106-110.

In recent years, improvements in veterinary care for cats has led to a steadily growing population of senior cats. This compels us to improve our understanding of and treatments for behavioral problems associated with this age group. Cognitive dysfunction (CD) can cause changes in behavior secondary to declining mental function. There is no specific test for CD; rather veterinarians must evaluate owner observations of changes in behavior and rule out other possible causes for these changes. Once CD has been diagnosed, treatment is multi-factorial. While several medications have been approved by the FDA to treat Alzheimer's disease in humans, only one approved drug exists for CD in animals and it is approved only for dogs (Anipryl; Pfizer). Other treatments include dietary therapy, and environmental and behavior modification. The goal is to improve the quality and prolong the duration of life in senior cats with CD.
>> PubMed abstract

Related articles:
Landsberg, G. (2006). "Therapeutic options for cognitive decline in senior pets." J Am Anim Hosp Assoc 42(6): 407-13.
>> PubMed abstract

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